Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Troglitazone, an euglycemic antidiabetic drug.

K Vyas1, A Sivalakshmidevi, C Prabhakar

  • 1Dr Reddy's Research Foundation, India.

Acta Crystallographica. Section C, Crystal Structure Communications
|April 30, 1999
PubMed
Summary

Troglitazone, the first euglycemic drug, is characterized by its molecular structure. Intermolecular hydrogen bonds within its lattice influence its properties.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment guidelines for rare, early-onset conditions associated with epileptic seizures: a literature review on Rett syndrome and tuberous sclerosis complex.

Orphanet journal of rare diseases·2024
Same author

Complete agenesis of the dorsal pancreas: Case report with imaging findings and review of the literature.

Malawi medical journal : the journal of Medical Association of Malawi·2015
Same author

Comparison of five commercially available immunochromatographic tests for the detection of norovirus in faecal specimens.

The Journal of hospital infection·2015
Same author

Clinician perceptions of pediatric growth chart use and electronic health records in Kentucky.

Applied clinical informatics·2013
Same author

Isolation and characterisation of degradant impurities in dipyridamole formulation.

Journal of pharmaceutical and biomedical analysis·2011
Same author

Detection of endogenous magnetic nanoparticles with a tunnelling magneto resistance sensor.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2010

Area of Science:

  • Medicinal Chemistry
  • Molecular Pharmacology
  • Crystallography

Background:

  • Troglitazone is the first euglycemic drug developed for therapeutic use.
  • Understanding the molecular interactions of Troglitazone is crucial for its pharmacological application.

Purpose of the Study:

  • To elucidate the molecular structure and bonding of Troglitazone.
  • To identify the specific intermolecular forces governing Troglitazone's crystal lattice.

Main Methods:

  • Chemical structure determination of Troglitazone (C24H27NO5S).
  • Analysis of intermolecular hydrogen bonding within the Troglitazone crystal lattice.

Main Results:

  • Troglitazone's structure involves a chroman moiety linked to a thiazolidine-2,4-dione moiety.
  • Intermolecular hydrogen bonds form between the hydroxyl group of the chroman and the ketone/ring nitrogen of the thiazolidine-2,4-dione.

Conclusions:

  • The specific hydrogen bonding network in Troglitazone's crystal lattice is defined.
  • This structural understanding contributes to the broader knowledge of euglycemic drug molecules.

Related Experiment Videos