[Membrane effect of potassium rhodanide and methotrexate]

In HeLa cells and macrophages rhodanide ions cause biological hyperpolarization of the cell membranes, while methotrexate hyperpolarizes the membranes as an antimetabolite. Cell physiologically, rhodanide has a general stimulating effect within the physiological control range of the cell. This membrane effect could be related to the physiological and therapeutic action of rhodanide in processes involving immunological events.