Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium accumulation in some endocrine tissues.

W D Pfeifer, L C Davis, C D van der Velde

    Acta Biologica Et Medica Germanica
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Relationships among performance, residual feed intake, and product quality of progeny from Red Angus sires divergent for maintenance energy EPD.

    Journal of animal science·2012
    Same author

    Fate of volatile chlorinated organic compounds in a laboratory chamber with alfalfa plants.

    Environmental science & technology·2012
    Same author

    Bovine sire selection based on maintenance energy affects muscle fiber type and meat color of F1 progeny.

    Journal of animal science·2011
    Same author

    Infrared monitoring of dinitrotoluenes in sunflower and maize roots.

    Journal of environmental quality·2011
    Same author

    Angular distribution of coherent Raman emission in degenerate four-wave mixing with pumping by a single diffraction coupled laser beam: configurations for high spatial resolution.

    Applied optics·2010
    Same author

    Meningococcal disease in a backpackers hostel in Scotland: a risk assessment for prophylaxis.

    Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2009

    This study tracked lithium levels in rat tissues, finding accumulation in the pituitary and thyroid. Lithium clearance varied by tissue, with the pituitary retaining higher levels post-administration.

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Toxicology

    Background:

    • Lithium is a mood stabilizer with a narrow therapeutic index.
    • Understanding lithium distribution and clearance in various tissues is crucial for safe and effective use.
    • The impact of lithium on the endocrine system requires further investigation.

    Purpose of the Study:

    • To quantify lithium levels in rat brain, pituitary, thyroid, and serum after oral administration.
    • To assess the pharmacokinetics of lithium clearance from these tissues.
    • To investigate the effect of lithium on corticosterone levels under basal and stress conditions.

    Main Methods:

    • Oral administration of lithium to rats for varying durations.
    • Measurement of lithium concentrations in serum and multiple tissue types.

    Related Experiment Videos

  • Analysis of adrenal and plasma corticosterone levels following electric footshock.

    • Main Results:

    • Lithium levels in the brain approximated serum concentrations.
    • Significant lithium accumulation was observed in the pituitary and thyroid glands.
    • The pituitary gland showed sustained elevated lithium levels post-cessation, while clearance varied across tissues.
    • Lithium administration increased both basal and stress-induced corticosterone levels.

    Conclusions:

    • Lithium exhibits tissue-specific distribution and accumulation, particularly in the pituitary and thyroid.
    • Lithium clearance is not uniform across tissues, with the pituitary demonstrating prolonged retention.
    • Lithium administration influences the hypothalamic-pituitary-adrenal axis, affecting corticosterone regulation.