Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reactive microgliosis.

W J Streit1, S A Walter, N A Pennell

  • 1Department of Neuroscience, University of Florida College of Medicine and Brain Institute, Gainesville 32610, USA. streit@ufbi.ufl.edu

Progress in Neurobiology
|April 30, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of clinical factors and recent anticancer therapy with COVID-19 severity among patients with cancer: a report from the COVID-19 and Cancer Consortium.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

Position of an international panel of lung cancer experts on the decision for expansion of approval for pembrolizumab in advanced non-small-cell lung cancer with a PD-L1 expression level of ≥1% by the USA Food and Drug Administration.

Annals of oncology : official journal of the European Society for Medical Oncology·2019
Same author

Phenotypic characterisation of cell populations in the brains of horses experimentally infected with West Nile virus.

Equine veterinary journal·2017
Same author

Abdominal pain is associated with anxiety and depression scores in a sample of the general adult population with no signs of organic gastrointestinal disease.

Neurogastroenterology and motility·2013
Same author

Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome.

Alimentary pharmacology & therapeutics·2013
Same author

Calcitonin gene-related peptide (CGRP) in the regenerating rat sciatic nerve.

Restorative neurology and neuroscience·2011
Same journal

Deletion of Fbxo25 causes excessive repetitive behavior, impaired recognition memory, reduced dendritic complexity, and aberrant protein expression in mice.

Progress in neurobiology·2026
Same journal

Neuropsychiatric Disease Mechanisms and Interventions. from 22q11.2 Deletion Syndrome Experimental Studies.

Progress in neurobiology·2026
Same journal

REM sleep as a dummy-model of the world: A theoretical framework.

Progress in neurobiology·2026
Same journal

CA3 transiently modulates spatial representation in CA1.

Progress in neurobiology·2026
Same journal

Love, death, and oxytocin: In memory of Larry Young.

Progress in neurobiology·2026
Same journal

Assessing peripheral oxytocin and cortisol levels and epigenetic variations of oxytocin receptor and glucocorticoid receptor genes in school-aged preterm-born children.

Progress in neurobiology·2026
See all related articles

Central nervous system (CNS) injury activates microglia, the brain's immune cells. This review clarifies microglial roles and interactions, distinguishing beneficial from harmful activation based on experimental context.

Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Central nervous system (CNS) damage triggers astrocyte and microglia activation.
  • Microglia are the primary immune cells within the CNS.
  • Understanding microglial responses is crucial for neuroinflammation research.

Purpose of the Study:

  • To review the key features of microglial activation following CNS injury.
  • To critically discuss microglial biology, including their relationship with macrophages and their role as immunocompetent cells.
  • To explore the mechanistic and functional aspects of microgliosis, focusing on microglial-neuronal interactions.

Main Methods:

  • Literature review and critical discussion of existing research on microglial activation.
  • Analysis of concepts related to microglial biology and function.

Related Experiment Videos

  • Examination of in vivo and in vitro experimental data on reactive microgliosis.

    • Main Results:

    • Microglial activation is a principal response to CNS injury.
    • Microglia function as immunocompetent cells within the CNS, distinct from peripheral macrophages.
    • The interpretation of 'activated microglia' differs between in vivo and in vitro studies.

    Conclusions:

    • Reactive microgliosis can be perceived as both beneficial and detrimental.
    • The functional outcome of microglial activation depends on the specific context and experimental conditions.
    • A nuanced understanding of microglial activation is essential for advancing CNS injury research.