Related Experiment Video
Updated: Oct 23, 2026
Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Retinopathy of prematurity: lack of association with prenatal care
R D Higgins1, A L Mendelsohn, M J DeFeo
1Department of Pediatrics, New York University Medical Center and Bellevue Hospital Center, New York, USA.
Insights
This study found that lack of prenatal care did not increase the risk of retinopathy of prematurity (ROP) in low birth weight infants. Further research is needed to understand ROP risk factors in this vulnerable population.
Area of Science:
- Neonatal Ophthalmology
- Perinatal Medicine
- Public Health
Background:
- Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
- Identifying modifiable risk factors for ROP is crucial for improving infant outcomes.
- Prenatal care is considered important for maternal and fetal health, but its specific impact on ROP is not fully understood.
Purpose of the Study:
- To prospectively evaluate risk factors for retinopathy of prematurity (ROP).
- To assess the association between prenatal care and ROP incidence in infants with birth weight less than 1250 grams.
- To test the hypothesis that lack of prenatal care increases ROP incidence.
Main Methods:
- A consecutive sample of infants weighing <1250 g at birth and surviving to ophthalmology screening was studied.
- Data collected included the presence or absence of ROP and prenatal care status.
- Clinical information relevant to ROP development was also gathered.
Main Results:
- Sixty-eight percent of the 90 evaluated infants had ROP; 32% did not.
- No significant differences in ROP incidence or severity were found between infants with and without prenatal care.
- Birth weight and gestational age did not differ between groups based on prenatal care status.
Conclusions:
- Lack of prenatal care was not associated with an increased risk of ROP in this urban cohort of very low birth weight infants.
- These findings suggest that other factors may play a more significant role in ROP development.
- Further investigation into diverse risk factors for ROP in premature infants is warranted.
Objectives:
The overall goal of this study was to prospectively assess risk factors for retinopathy of prematurity (ROP) in infants of birth weight <1250 g in an urban population at Bellevue Hospital Center, New York, New York. The hypothesis tested was that lack of prenatal care increases the incidence of ROP.
Methods:
A consecutive sample of patients admitted to Bellevue Hospital Center's neonatal intensive care unit/special care nursery who weighed <1250 g at birth and survived until their ophthalmology screening examinations were included in the study. The main outcome measures were presence or absence of ROP and prenatal care. Additional relevant clinical information was collected on the patients.
Results:
Ninety infants were evaluated. Sixty-one (68%) had ROP; 29 (32%) had no ROP. No differences in incidence or severity of ROP were detected with regard to prenatal care when the 2 groups were compared. In this population <1250 g, there were no differences in birth weight or gestational age with respect to prenatal care or lack of prenatal care.
Conclusions:
Lack of prenatal care was not associated with an increased risk for ROP in infants with birth weight <1250 g in this urban population.
Related Concept Videos
01:27Diabetic Retinopathy
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:22Photoreceptors and Visual Pathways