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Clonal differences among erythromycin-resistant Streptococcus pyogenes in Spain.

E Perez-Trallero1, J M Marimón, M Montes

  • 1Universidad del País Vasco, San Sebastián, Spain. labmikro@teleline.es

Emerging Infectious Diseases
|April 30, 1999
PubMed
Summary
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High erythromycin resistance in Streptococcus pyogenes in Spain is linked to specific clones. The study identified major clones responsible for the spread of this resistance, primarily through an efflux mechanism.

Area of Science:

  • Microbiology
  • Genetics
  • Epidemiology

Background:

  • Streptococcus pyogenes exhibits high levels of erythromycin resistance in Spain.
  • Understanding the genetic and clonal basis of this resistance is crucial for public health.

Purpose of the Study:

  • To investigate if specific clones of Streptococcus pyogenes are responsible for high erythromycin resistance in Spain.
  • To characterize erythromycin-resistant S. pyogenes strains using phenotypic and genotypic methods.

Main Methods:

  • Phenotypic and genotypic characterization of erythromycin-resistant S. pyogenes (ErR) strains.
  • Techniques included biotyping, T serotyping, emm typing, and genotyping.
  • Pulsed-field gel electrophoresis (PFGE) was used for clonal analysis.

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Main Results:

  • 97% of 437 ErR strains exhibited the M phenotype, with mefA being the resistance determinant.
  • Four major clones were identified among the ErR strains.
  • Clones B and D accounted for 78.8% of all ErR strains, indicating clonal spread.

Conclusions:

  • Erythromycin resistance in Streptococcus pyogenes in Spain is largely driven by a limited number of clones.
  • The M phenotype, mediated by mefA, is the predominant mechanism of resistance.
  • Clonal dissemination plays a significant role in the epidemiology of erythromycin resistance in S. pyogenes.