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Related Experiment Videos

Sick euthyroid syndrome. What to do when thyroid function tests are abnormal in critically ill patients.

P M Camacho1, A A Dwarkanathan

  • 1Loyola University Medical Center, Division of Endocrinology and Metabolism, Maywood, IL 60153, USA. jonola@aol.com

Postgraduate Medicine
|May 1, 1999
PubMed
Summary

Abnormal thyroid hormone levels are common in severe nonthyroidal illnesses and may predict patient outcomes. Thyroid function typically normalizes after recovery, but the benefit of hormone supplementation needs further study.

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Area of Science:

  • Endocrinology
  • Internal Medicine
  • Critical Care Medicine

Background:

  • Serious nonthyroidal illnesses frequently cause abnormal thyroid hormone concentrations.
  • Thyroid function test abnormalities in these patients are usually reversible upon recovery.
  • Emerging evidence suggests a potential prognostic role for thyroid hormone levels.

Purpose of the Study:

  • To review the current understanding of thyroid hormone abnormalities in nonthyroidal illnesses.
  • To discuss the implications for patient prognosis.
  • To address the controversy surrounding thyroid hormone supplementation.

Main Methods:

  • Review of existing literature on thyroid function in nonthyroidal illnesses.
  • Analysis of early evidence linking thyroid hormone levels to prognosis.

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  • Discussion of clinical management strategies and future research directions.

    • Main Results:

    • Abnormal thyroid hormone levels are a common finding in patients with severe nonthyroidal illnesses.
    • Thyroid hormone levels may serve as predictive markers for patient prognosis in certain conditions.
    • Thyroid function tests generally normalize once the underlying illness resolves.

    Conclusions:

    • Abnormal thyroid function associated with nonthyroidal illness is typically reversible.
    • Repeat thyroid function testing is recommended after resolution of the acute illness.
    • The efficacy of active intervention with thyroid hormone supplements remains uncertain and requires further large-scale investigation.