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[Multifocal invasive Kingella kingae infection]
H Sarda1, D Ghazali, M Thibault
1Service de pédiatrie, hôpital Victor-Dupouy, Argenteuil, France.
Insights
Kingella kingae, a bacterium causing severe infections like septicemia, meningitis, and endocarditis in children, can be successfully treated with adjusted antibiotic therapy. This case highlights favorable outcomes with appropriate antimicrobial treatment strategies.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Microbiology
- Bacteriology
Background:
- Kingella kingae is an increasingly recognized cause of invasive infections in young children.
- This bacterium typically requires specific culture media for isolation and identification.
- Osteoarticular and cardiac infections are common manifestations of Kingella kingae.
Observation:
- A 2-year-old, non-immunodeficient child presented with severe septicemia caused by Kingella kingae.
- The infection progressed to meningitis, arthritis of the knee, and endocarditis.
- The patient received a prolonged course of adjusted antibiotic therapy.
Findings:
- Successful treatment of Kingella kingae endocarditis involved a combination of ceftriaxone and amikacin, followed by oral amoxicillin.
- The overall outcome for the child was favorable despite the severe and disseminated nature of the infection.
- Kingella kingae demonstrates tropism for osteoarticular and cardiac systems.
Implications:
- This case underscores the importance of considering Kingella kingae in the differential diagnosis of invasive pediatric infections.
- Prompt and appropriate antibiotic selection is crucial for favorable outcomes in invasive Kingella kingae infections.
- Understanding the bacteriologic characteristics and antibiotic susceptibility of Kingella kingae aids in effective clinical management.
Case Report:
A 2-year-old child, non immunodeficient, presented with septicemia due to Kingella kingae successively complicated by meningitis, arthritis of one knee and endocarditis. Outcome was favourable after a long and adjusted antibiotherapy, involving in particular for the endocarditis ceftriaxone (100 mg/kg/d) and amikacin (20 mg/kg/d) during 3 weeks, then amoxicillin per os (200 mg/kg/d) during 3 weeks.
Conclusions:
Bacteriologic characteristics of the bacteria, the culture of which requires medium base with additional nutrient are reviewed. The tropism of Kingella kingae is essentially osteoarticular and cardiac as shown by the cases reported in the literature. Its susceptibility to antibiotics explains the frequent favourable outcome.