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Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction
Insights
Choroid plexus papilloma significantly increases cerebrospinal fluid (CSF) production. Surgical removal of the tumor drastically reduced CSF formation, indicating the tumor
Area of Science:
- Neuroscience
- Pediatric Neurosurgery
- Cerebrospinal Fluid Dynamics
Background:
- Choroid plexus papillomas are rare tumors that can cause hydrocephalus.
- Understanding the impact of these tumors on cerebrospinal fluid (CSF) dynamics is crucial for effective treatment.
Observation:
- A 2-year-old child with a choroid plexus papilloma underwent CSF formation rate assessment using a ventricular perfusion technique.
- Preoperative CSF formation rate was measured at 1.05 ± 0.01 ml/min (1,656 ml/day).
Findings:
- Postoperative CSF formation rate decreased fivefold to 0.20 ± 0.01 ml/min (288 ml/day) after tumor removal.
- These findings provide conclusive evidence of CSF overproduction by the choroid plexus papilloma.
Implications:
- Choroid plexus papillomas are a significant source of CSF overproduction.
- While tumor removal reduces CSF production, obstruction of subarachnoid pathways can also contribute to ventricular enlargement.
Abstract:
Utilizing a ventricular perfusion technique, the rate of CSF formation was determined in a 2-year-old child before and after removal of a 74 g choroid plexus papilloma from the left lateral ventricle. Preoperatively, the CSF formation rate was 1.05 +/- SD 0.01 ml/min (1,656 ml/day). Postoperatively, the CSF formation rate was reduced fivefold to 0.20 +/- SD 0.01 ml/min (288 ml/day). Whereas these data are regarded as conclusive evidence of CSF overproduction by a choroid plexus papilloma, the pathogenesis of generalized ventricular enlargement in this case was due to part to obstruction of the subarachnoid pathways.