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Updated: Oct 23, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Direct resolution of optically active isomers on chiral packings containing ergoline skeleton. 6. Enantioseparation
J Olsovská1, M Flieger, F Bachechi
1Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Abstract:
The enantioselective behaviour of some underivatized 2-arylpropionic acids (profens) and flobufen by HPLC using a terguride-based chiral stationary phase was tested. X-ray analysis of crystals of the chiral selector and its complexes with naproxen allowed a deeper insight into the enantiodiscriminative process. The column stability and reproducibility, and the potential of the packing for semipreparative scale separations were also determined. A method for determining flobufen enantiomers and metabolites in plasma samples is described.
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