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[Renal gravel formation inducing renal insufficiency as a side-effect of ceftriaxon]
Orvosi Hetilap
|May 4, 1999
Insights
Ceftriaxone, a common pediatric antibiotic, can cause kidney stones. A case study highlights ceftriaxone-associated cholelithiasis and nephrolithiasis leading to severe kidney issues in a child.
Area of Science:
- Pharmacology
- Pediatric Nephrology
- Adverse Drug Reactions
Background:
- Ceftriaxone is a widely used third-generation cephalosporin antibiotic with broad-spectrum antimicrobial activity.
- Its use in pediatric populations is common for various infections.
- Potential adverse effects, including renal complications, warrant careful consideration.
Observation:
- A case report details a 9-year-old boy who developed gallstones (cholelithiasis) and kidney stones (nephrolithiasis).
- These conditions were directly associated with ceftriaxone treatment.
- The severity of the stones led to anuria (lack of urine production) and uremia (a buildup of waste products in the blood).
Findings:
- Ceftriaxone administration was linked to the formation of both gallstones and kidney stones in a pediatric patient.
- The renal lithiasis resulted in acute kidney injury, manifesting as anuria and uremia.
- This case underscores a rare but serious side effect of ceftriaxone therapy.
Implications:
- Clinicians should be aware of the potential for ceftriaxone-induced cholelithiasis and nephrolithiasis, especially in pediatric patients.
- Monitoring for renal complications may be necessary in children receiving prolonged or high-dose ceftriaxone therapy.
- This finding highlights the importance of evaluating drug-induced nephrotoxicity and its clinical consequences.
Abstract:
Ceftriaxon is a third-generation cephalosporin with a wide and powerful spectrum of antimicrobal activity. It is often used in pediatrics. The authors draw the attention to the side-effect of the medicament, which might cause renal gravel-formation. They report a case of a 9-years old boy, who suffered from ceftriaxone-associated cholelithiasis and hephrolithiasis, which induced anuria and uraemia.