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Related Experiment Videos

Cardiac nociception induced rectal response: relation with haemodynamic changes.

J Koley1, A K Basak, M Das

  • 1Department of Physiology, University College of Science, Calcutta.

Indian Journal of Physiology and Pharmacology
|May 4, 1999
PubMed
Summary
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Nicotine applied to the heart caused biphasic rectal changes and blood pressure alterations in cats. These cardiorectal reflexes, mediated by the left inferior cardiac nerve, are distinct from blood pressure changes induced by coronary artery occlusion.

Area of Science:

  • Cardiovascular Physiology
  • Gastrointestinal Motility
  • Autonomic Nervous System Regulation

Background:

  • The relationship between cardiac stimulation and gastrointestinal responses, specifically rectal motility, is not fully understood.
  • Investigating the neural pathways and mechanisms underlying cardiorectal reflexes is crucial for understanding autonomic regulation.

Purpose of the Study:

  • To investigate the effects of epicardial nicotine and left anterior descending coronary artery (LAD) occlusion on rectal motility and blood pressure in cats.
  • To elucidate the role of ventricular receptors, the left inferior cardiac nerve (LICN), and specific neurotransmitters in mediating cardiorectal reflexes.

Main Methods:

  • Epicardial application of nicotine and lignocaine to the left ventricle.
  • Occlusion of the left anterior descending coronary artery (LAD).

Related Experiment Videos

  • Sectioning and stimulation of the left inferior cardiac nerve (LICN).
  • Pharmacological interventions including atropinization and NG-nitro-L-Arginine (LNNA) administration.

    • Main Results:

    • Epicardial nicotine induced biphasic changes in rectal motility (relaxation followed by contraction) and blood pressure.
    • LAD occlusion primarily caused hypotension.
    • Lignocaine abolished nicotine-induced responses but not LAD occlusion hypotension.
    • LICN sectioning abolished cardiorectal reflexes but not blood pressure changes.
    • Atropine affected the contractile phase, while LNNA affected the relaxation phase of the cardiorectal reflex.

    Conclusions:

    • Cardiorectal reflexes, elicited by epicardial nicotine, involve distinct neural pathways and neurotransmitter systems (cholinergic and nitrergic).
    • These reflexes are modulated by ventricular receptors and the LICN.
    • The cardiorectal reflexes are dissociated from the blood pressure changes induced by LAD occlusion, suggesting independent regulatory mechanisms.