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Updated: Aug 14, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Pleural perforation of an aspergilloma cavity occurring in a patient with interstitial lung disease
E Peeva1, S Alam, V Jimenez-Lucho
1Northport Veterans Affairs Medical Center and Department of Medicine, State University of New York at Stony Brook, USA.
Abstract:
An aspergilloma is a fungus ball resulting from colonization of pre-existing pulmonary cavities, which usually represents a non-invasive form of aspergillosis. Spontaneous rupture of the cavity containing the fungi into the pleural space is an unusual complication that has been reported occasionally in patients with leukemia and invasive aspergillosis. We report on this unusual complication occurring in a patient with underlying interstitial lung disease, in whom the aspergilloma cavity abruptly ruptured into the pleural space with subsequent hydropneumothorax and pleural spillage of the fungi.
Insights
A rare complication of aspergilloma, a fungus ball in lung cavities, is spontaneous rupture into the pleural space. This case highlights this unusual event in a patient with interstitial lung disease, leading to hydropneumothorax.
Area of Science:
- Pulmonology
- Mycology
- Radiology
Background:
- Aspergilloma, a non-invasive form of aspergillosis, forms within pre-existing lung cavities.
- Rupture into the pleural space is a rare complication, typically seen with invasive aspergillosis in leukemia patients.
Observation:
- A patient with underlying interstitial lung disease presented with a sudden complication.
- The aspergilloma cavity spontaneously ruptured, leading to pleural space involvement.
Findings:
- The rupture resulted in a hydropneumothorax, characterized by air and fluid in the pleural space.
- Fungal elements (aspergilloma) were observed spilled into the pleural space.
Implications:
- This case expands the known clinical presentations of aspergilloma complications.
- Highlights the importance of considering aspergilloma rupture in patients with lung cavities and interstitial lung disease presenting with pleural effusion or pneumothorax.
- Suggests potential for novel diagnostic and management strategies for this rare event.
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