Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pathogenesis of reactive arthritis.

¹Department of Medicine, University of California, Los Angeles 90095-167022, USA. dtyyu@ucla.edu

Internal Medicine (Tokyo, Japan)

|May 4, 1999

Summary

Reactive arthritis, a spondyloarthropathy, involves bacterial triggers and a TH1 lymphocyte response in joints. The Human Leukocyte Antigen (HLA)-B27 gene influences this immune response, potentially leading to arthritis development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of quality of life using ASQoL questionnaire in patients with ankylosing spondylitis in a Chinese population.

Rheumatology international·2006

Same author

A neuroprosthesis for high tetraplegia.

The journal of spinal cord medicine·2001

Same author

Correlates of acute renal failure in patients receiving parenteral amphotericin B.

Kidney international·2001

Same author

Comparing stimulation-induced pain during percutaneous (intramuscular) and transcutaneous neuromuscular electric stimulation for treating shoulder subluxation in hemiplegia.

Archives of physical medicine and rehabilitation·2001

Same author

Expression of host defense scavenger receptors in spondylarthropathy.

Arthritis and rheumatism·2001

Same author

The modulation of chlamydial replication by HLA-B27 depends on the cytoplasmic domain of HLA-B27.

Clinical and experimental rheumatology·2001

Area of Science:

Immunology
Rheumatology
Microbiology

Background:

Reactive arthritis is a type of spondyloarthropathy.
Bacterial infections of mucosal surfaces can trigger reactive arthritis.
The pathogenesis involves immune responses within the joints.

Purpose of the Study:

To elucidate the immunological mechanisms underlying reactive arthritis.
To understand the role of specific immune cells and genetic factors in disease development.

Main Methods:

Analysis of the T lymphocyte response (TH1, oligoclonal T cells, peptide-specific CD8+ T cells) in affected joints.
Investigation of the influence of Human Leukocyte Antigen (HLA)-B27 on immune cell function and bacterial interaction.

Main Results:

A TH1 lymphocyte response, involving oligoclonal T lymphocytes and peptide-specific CD8+ T lymphocytes, is central to reactive arthritis pathogenesis.
The Human Leukocyte Antigen (HLA)-B27 gene plays a significant role.
HLA-B27 modifies cellular responses to bacteria, affecting bacterial fate and cytokine release.

Conclusions:

Reactive arthritis results from a complex interplay between bacterial triggers and host immune responses.
HLA-B27 is a key genetic factor that modulates the immune response to bacteria, contributing to arthritis development through altered bacterial handling and cytokine production.

Related Experiment Videos