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Related Experiment Videos

Changes in donor apheresis in Japan.

S Sekiguchi, N Sato, S Yamamoto

    Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis
    |May 4, 1999
    PubMed
    Summary

    Donor apheresis significantly boosted Japan's blood supply, increasing plasma and platelet products. This technique also enhances safety by reducing leukocytes and is crucial for stem cell transplantation.

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    Area of Science:

    • Hematology
    • Transfusion Medicine
    • Oncology

    Background:

    • Donor apheresis was implemented in Japan in 1986 to augment source plasma collection.
    • This led to a substantial increase in total source plasma volume and self-sufficiency for Factor VIII.
    • Platelet product supply saw rapid growth, with apheresis becoming the primary collection method.

    Discussion:

    • Platelet apheresis ensures product sufficiency and offers the advantage of reduced residual leukocytes, minimizing donor antigen exposure and febrile reactions.
    • Apheresis techniques are increasingly utilized in cancer therapy, particularly for peripheral blood stem cell (PBSC) transplantation.
    • This method is effective in collecting sufficient progenitor cells for both autologous and allogeneic transplantation.

    Key Insights:

    • Donor apheresis dramatically improved Factor VIII self-sufficiency from below 10% to 100% between 1991 and 1994.
    • Over 99.99% of platelet products in Hokkaido were collected via apheresis by 1995, highlighting its indispensability.
    • Apheresis facilitates the collection of essential progenitor cells for stem cell transplantation, with high success rates.

    Outlook:

    • Apheresis is poised to become increasingly vital in transfusion medicine and cancer therapy.
    • Continued advancements in apheresis technology will further enhance blood product availability and patient outcomes.
    • The role of apheresis in supporting bone marrow transplantation alternatives like PBSC transplantation is expected to expand.

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