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Apheresis techniques and cellular immunomodulation.

J W Smith1

  • 1Oklahoma Blood Institute, Oklahoma City 73104, USA.

Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis
|August 1, 1997
PubMed
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Advances in white blood cell (WBC) removal techniques offer new therapeutic options and improve blood product safety. These methods enhance cellular immunotherapy and reduce adverse immune effects in recipients.

Area of Science:

  • Hematology
  • Immunology
  • Biotechnology

Background:

  • White blood cells (WBCs) play crucial roles in immunity but can cause adverse effects in transfusion recipients.
  • WBCs also have therapeutic potential, such as granulocytes for sepsis and mononuclear cells for stem cell transplantation.

Purpose of the Study:

  • To review advances in WBC removal techniques.
  • To explore their applications in transfusion medicine and cellular immunotherapy.

Main Methods:

  • Centrifugal and filtration techniques for WBC removal.
  • Apheresis for collecting specific WBC subsets (granulocytes, mononuclear cells).
  • Leukoreduction filters and newer centrifugal adaptations for WBC reduction.

Main Results:

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  • WBC removal techniques effectively reduce WBC counts in blood products.
  • Therapeutic applications include sepsis treatment, stem cell transplantation, and treatment of autoimmune diseases.
  • Emerging adsorbent filters show promise for selective WBC removal in online filtration therapy.

Conclusions:

  • WBC removal technologies have significantly advanced transfusion medicine and cellular immunotherapy.
  • These techniques offer both prophylactic benefits (reducing immune reactions) and therapeutic potential (harnessing immunomodulatory effects).
  • Further development in selective WBC adsorption techniques is expected to enhance future cellular immunotherapies.