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Endocytosis: How dynamin sets vesicles PHree!
M J Bottomley1, P Lo Surdo, P C Driscoll
1Structural Biology Programme, EMBL, Meyerhofstrasse 1, Heidelberg 69117, Germany.
Current Biology : CB
|May 5, 1999
Abstract:
The dynamin GTPase is required for clathrin-dependent, receptor-mediated endocytosis. Exciting new studies have shown that dynamin's pleckstrin homology domain binds to phosphatidylinositol 4, 5-bisphosphate in vivo, thus localising dynamin directly at the plasma membrane and ultimately enabling vesiculation.