Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microtubule dynamics: Controlling split ends.

F J McNally1

  • 1Section of Molecular and Cellular Biology, University of California at Davis, Davis, California 95616, USA. fjmcnally@ucdavis.edu

Current Biology : CB
|May 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cytoskeleton: CLASPing the end to the edge.

Current biology : CB·2001
Same author

MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis.

Genes & development·2000
Same author

Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin.

Journal of cell science·2000
Same author

An essential role for katanin in severing microtubules in the neuron.

The Journal of cell biology·1999
Same author

Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.

Molecular biology of the cell·1998
Same author

A role for katanin-mediated axonemal severing during Chlamydomonas deflagellation.

Molecular biology of the cell·1998
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Microtubule dynamics, crucial for cell functions, involve rapid growth and shrinkage. New research on microtubule structure and regulators like XKCM1 and OP18 explains how these dynamic switching events are controlled.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Microtubules are dynamic polymers essential for cell division, intracellular transport, and cell structure.
  • The dynamic instability of microtubules, characterized by rapid transitions between growth and shrinkage, is fundamental to cellular processes.
  • Understanding the regulation of microtubule dynamics is key to comprehending cellular function and dysfunction.

Purpose of the Study:

  • To elucidate the regulatory mechanisms underlying the rapid switching between microtubule growth and shrinkage.
  • To investigate the roles of specific microtubule regulators, XKCM1 and OP18, in controlling microtubule dynamics.
  • To correlate structural insights of microtubules with their functional regulation.

Main Methods:

Related Experiment Videos

  • Analysis of recent structural studies on microtubule architecture.
  • Examination of the mechanism of action of microtubule-associated proteins XKCM1 and OP18.
  • Integration of structural and mechanistic data to explain dynamic switching events.

    • Main Results:

    • Recent structural studies provide insights into microtubule lattice conformation.
    • The microtubule regulators XKCM1 and OP18 were shown to influence microtubule polymerization and depolymerization rates.
    • These regulators act by modulating the structural transitions at microtubule ends, thereby controlling growth and shrinkage.

    Conclusions:

    • The interplay between microtubule structure and the action of regulators like XKCM1 and OP18 dictates dynamic instability.
    • Understanding these molecular mechanisms offers a basis for exploring therapeutic interventions targeting microtubule dynamics.