Related Experiment Video
Updated: Aug 12, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Nitric oxide in interstitial nephritis and other autoimmune diseases
Abstract:
Nitric oxide can be generated by macrophages, as well as many other cell types, through a cytokine inducible isoform of nitric oxide synthase. Historically the effector functions ascribed to iNOS-generated NO have been the control of intracellular organisms and tumor cell cytotoxicity. However, there is a growing appreciation that iNOS generated NO can additionally play an important role in immunoregulation. In this review, the authors outline the effects of iNOS inhibition or genetic deletion on the expression of several autoimmune diseases and discuss potential mechanisms underlying the immunosuppressive effects of NO.
More Related Videos
Related Concept Videos
Nitric Oxide Signaling Pathway
Acute Pyelonephritis I: Introduction
Acute Kidney Injury II: Pathophysiology
Inflammatory Bowel Disease III: Crohn's Disease

