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Type-2 IGF receptor: a multi-ligand binding protein
1Institute for Biochemistry II, Georg-August-Universität Göttingen, Germany. braulke@uni-bc2.gwdg.de
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|May 5, 1999
Summary
The Type-2 insulin-like growth factor receptor (IGF2R) regulates extracellular IGF II levels and may act as a tumor suppressor. Its expression and function are altered in various cancers.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- The Type-2 insulin-like growth factor receptor (IGF2R) is a 300 kDa glycoprotein.
- It binds multiple ligands including IGF II, lysosomal enzymes, retinoic acid, and urokinase-type plasminogen activator receptor.
- IGF2R's intracellular transport and function depend on its cytoplasmic domain interactions.
Purpose of the Study:
- To investigate the role of IGF2R in regulating extracellular IGF II concentration.
- To explore the potential tumor suppressor function of IGF2R.
- To understand the developmental regulation and signaling mechanisms of IGF2R.
Main Methods:
- Gene targeting experiments in mammals.
- Analysis of IGF2R and ligand expression in normal tissues and tumors.
- Studies on receptor-mediated endocytosis and protein degradation pathways.
Main Results:
- IGF2R expression is developmentally regulated and coordinated with IGF II in most mammalian tissues.
- Gene targeting suggests IGF2R controls extracellular IGF II via endocytosis and lysosomal degradation.
- Altered IGF2R expression and function are observed in human and rodent tumors.
Conclusions:
- IGF2R plays a crucial role in modulating IGF II bioavailability.
- Evidence suggests IGF2R functions as a tumor suppressor.
- Further research into IGF2R's role in cancer is warranted.