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Elevated levels of circulating immunostimulatory 90K in Henoch-Schoenlein purpura
P Pelliccia1, C Natoli, M T Petitti
1Department of Medicine, University of Chieti, Italy.
Insights
Henoch-Schoenlein purpura (HSP) involves elevated levels of 90K/Mac-2 BP and soluble intercellular adhesion molecule 1. These findings suggest 90K/Mac-2 BP may contribute to the immunological aspects of HSP.
Area of Science:
- Immunology
- Pediatrics
- Rheumatology
Background:
- Henoch-Schoenlein purpura (HSP) is a common childhood vasculitis.
- The specific immunological mechanisms underlying HSP require further clarification.
Purpose of the Study:
- To investigate the role of 90K/Mac-2 BP and soluble intercellular adhesion molecule 1 (sICAM-1) in the immunopathology of HSP.
- To compare serum levels of these molecules in children with HSP versus healthy controls.
Main Methods:
- Studied 20 children with HSP and 20 age- and sex-matched healthy controls.
- Measured serum concentrations of 90K/Mac-2 BP and sICAM-1 using established assays.
- Analyzed data for significant differences and correlations between groups.
Main Results:
- Significantly higher serum concentrations of 90K/Mac-2 BP were found in HSP patients compared to controls (P < 0.0001).
- Elevated sICAM-1 levels were also observed in HSP patients (P < 0.0001).
- A strong positive correlation was found between 90K/Mac-2 BP and sICAM-1 serum levels (r = 0.90, P < 0.0001).
Conclusions:
- The study indicates elevated 90K/Mac-2 BP and sICAM-1 levels in children with HSP.
- These findings suggest a potential role for 90K/Mac-2 BP in the immunological processes contributing to HSP development.
Abstract:
In order to clarify the immunologic reaction present in Henoch-Schoenlein purpura (HSP), 20 children (11 boys and 9 girls; median age, 5.8 +/- 2.8 years) with HSP and 20 sex- and age-matched healthy children were studied. The 90K/Mac-2 BP serum concentrations were significantly higher in the patients than in the healthy controls (12.5 +/- 7.5 vs 4.5 +/- 2.7 micrograms/ml, respectively; P < 0.0001). 90K/Mac-2 BP values higher than the cutoff value were observed in 13 of 20 (65%) patient. The soluble intercellular adhesion molecule 1 concentrations were significantly higher in HSP patients than controls (P < 0.0001), with mean values of 1631 +/- 703 and 85 +/- 16 ng/ml, respectively. The 90K/Mac-2 BP serum levels were significantly correlated with soluble intercellular adhesion molecule 1 (r = 0.90, P < 0.0001). Although the underlying causes of these immunological abnormalities are unclear, these observations suggest that the 90K/Mac-2 BP protein may play a role in the immunological reactions involved in the development of HSP.
