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Related Experiment Videos

Phytoestrogen intake and prostate cancer: a case-control study using a new database.

S S Strom1, Y Yamamura, C M Duphorne

  • 1Department of Epidemiology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.

Nutrition and Cancer
|May 5, 1999
PubMed
Summary

Phytoestrogen intake may influence prostate cancer risk. Certain phytoestrogens like coumestrol and daidzein showed inverse associations, while campesterol and stigmasterol showed positive associations with prostate cancer risk.

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Area of Science:

  • Nutritional Science
  • Oncology
  • Epidemiology

Background:

  • Dietary patterns, such as Western vs. Asian diets, are linked to differing prostate cancer rates.
  • Phytoestrogens, plant compounds found in the Asian diet, are investigated for potential anticarcinogenic effects.

Purpose of the Study:

  • To investigate the association between phytoestrogen intake and prostate cancer risk.
  • To compare the intake of specific phytoestrogens between prostate cancer cases and controls.

Main Methods:

  • A case-control study involving 83 Caucasian prostate cancer cases and 107 controls.
  • Dietary intake of phytoestrogens (genistein, daidzein, coumestrol, campesterol, stigmasterol) was assessed.
  • Multivariate analysis adjusted for age, family history, alcohol, and calorie intake.

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Main Results:

  • Higher intake of genistein, daidzein, and coumestrol was reported by controls.
  • Inverse association found between coumestrol (p=0.03) and daidzein (p=0.07) with prostate cancer risk.
  • Positive association found between campesterol (p=0.08) and stigmasterol (p=0.03) and prostate cancer risk.

Conclusions:

  • Phytoestrogen intake may be related to prostate cancer risk.
  • Specific phytoestrogens may have differential effects on prostate cancer risk.
  • Further large-scale studies are required to confirm these findings.