Inhibition of autoreactive antibody effects with antibody feedings: a pilot study
1Department of Neurology and Neurosciences, VA Medical Center, Stanford University School of Medicine, Palo Alto, CA 94305, USA.
This study seeks to determine if tolerance to autoreactive antibody can be achieved by exposing gut-associated lymphocytic tissue (GALT) to the protein. The method involved immunizing rats with AchR after feeding anti-AchR purified from myasthenic plasma or non-specific, pooled human immunoglobulins. Both feedings improved the neuromuscular block of EAMG, the commercial preparation requiring a tenfold increase in protein concentration. Despite its protective effect, antibody feeding was associated with late levels of serum anti-AchR considerably above those in immunized controls. The hypothesis presented is that the tolerance results from enhanced anti-idiotype production.
This study seeks to determine if tolerance to autoreactive antibody can be achieved by exposing gut-associated lymphocytic tissue (GALT) to the protein. The method involved immunizing rats with AchR after feeding anti-AchR purified from myasthenic plasma or non-specific, pooled human immunoglobulins. Both feedings improved the neuromuscular block of EAMG, the commercial preparation requiring a tenfold increase in protein concentration. Despite its protective effect, antibody feeding was associated with late levels of serum anti-AchR considerably above those in immunized controls. The hypothesis presented is that the tolerance results from enhanced anti-idiotype production.
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