Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The CHART regimen and morbidity.

S Dische1, M I Saunders

  • 1Mount Vernon Hospital, Northwood, Middlesex, UK.

Acta Oncologica (Stockholm, Sweden)
|May 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

To restore coastal marine areas, we need to work across multiple habitats simultaneously.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Abstracts from the 8th Annual Meeting of the Scientific Association of Swiss Radiation Oncology (SASRO).

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
Same author

Impact of sea-level rise and coral mortality on the wave dynamics and wave forces on barrier reefs.

Marine pollution bulletin·2014
Same author

Phase Ib trial of radiotherapy in combination with combretastatin-A4-phosphate in patients with non-small-cell lung cancer, prostate adenocarcinoma, and squamous cell carcinoma of the head and neck.

Annals of oncology : official journal of the European Society for Medical Oncology·2011
Same author

Adaptive 18fluoro-2-deoxyglucose positron emission tomography/computed tomography-based target volume delineation in radiotherapy planning of head and neck cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2010
Same author

Carbogen breathing increases prostate cancer oxygenation: a translational MRI study in murine xenografts and humans.

British journal of cancer·2009
Same journal

Pathological characteristics and prognosis of very young patients with early breast cancer: a comparative analysis with older patients.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Recent survival trends in the most fatal cancers in the Nordic countries: gains in some but not in all.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

First-in-human quantitative [¹⁵O]H₂O PET imaging of tumour blood flow at rest and during exercise in lymphoma patients.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Starshot field configuration in the linac isocentre size determination: a comparison of film and electronic portal imaging device measurements.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Perspectives on artificial intelligence-generated chronic disease risk predictions in early breast cancer: an international survey among radiation oncologists.

Acta oncologica (Stockholm, Sweden)·2026
Same journal

Evaluation of 3D-CRT vs. VMAT for radiotherapy of whole breast with simultaneous integrated boost.

Acta oncologica (Stockholm, Sweden)·2026
See all related articles

The Continuous Hyperfractionated Accelerated Radiotherapy (CHART) regime resulted in more severe acute mucosal reactions but fewer acute skin reactions. Late effects in normal tissues were reduced, though less than predicted, with central nervous system dose restrictions implemented.

Area of Science:

  • Radiation Oncology
  • Clinical Oncology
  • Radiotherapy Techniques

Background:

  • The Continuous Hyperfractionated Accelerated Radiotherapy (CHART) regime was developed in 1984 with predictions of increased acute reactions but reduced late effects.
  • A pilot study (1985-1990) and randomized trials (1990-1995) were conducted to evaluate CHART's efficacy and toxicity.

Purpose of the Study:

  • To review the findings from clinical studies evaluating the CHART regime.
  • To assess the acute and late effects of CHART on normal tissues.
  • To compare observed outcomes with the initial predictions for the CHART regime.

Main Methods:

  • Review of data from a pilot study and randomized clinical trials of the CHART regime.
  • Analysis of acute reactions in skin and mucosae.

Related Experiment Videos

  • Evaluation of late effects in normal tissues, including the central nervous system.

    • Main Results:

    • CHART led to more severe, though tolerable and recoverable, acute mucosal reactions.
    • Unexpectedly, acute skin reactions were reduced with CHART.
    • Late effects in normal tissues were significantly reduced, but less than predicted.
    • Central nervous system toxicity necessitated a dose restriction to 40 Gy.

    Conclusions:

    • The CHART regime demonstrates a complex pattern of acute and late toxicity.
    • The observed sparing of normal tissues was less than anticipated, potentially due to slower sublethal injury repair in human tissues.
    • Further research into tissue repair mechanisms may inform future radiotherapy fractionation strategies.