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A DLST genotype associated with reduced risk for Alzheimer's disease
K F Sheu1, A M Brown, B S Kristal
1Burke Medical Research Institute, Cornell University Medical College, White Plains, NY 10605, USA.
Neurology
|May 5, 1999
Abstract:
Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.