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[Ketamine].

J A Reboso Morales1, F González Miranda

  • 1Servicio de Anestesiología y Reanimación, Hospital Universitario de Canarias, Tenerife.

Revista Espanola De Anestesiologia Y Reanimacion
|May 6, 1999
PubMed
Summary

Ketamine is a versatile intravenous drug providing anesthesia, sedation, and analgesia. It is a viable option for various patient groups and surgical procedures, with co-administration of propofol or midazolam mitigating side effects.

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Ketamine is a unique drug with anesthetic, sedative, amnesiac, and analgesic properties.
  • It remains a viable anesthetic agent despite sometimes being overlooked.
  • Its water-soluble, stable, and non-irritant properties facilitate intravenous administration.

Purpose of the Study:

  • To review the properties and applications of ketamine in anesthesia and analgesia.
  • To highlight its utility in various patient populations and clinical scenarios.
  • To discuss methods for mitigating ketamine's adverse effects.

Main Methods:

  • Review of existing literature on ketamine's pharmacological profile and clinical uses.
  • Analysis of ketamine's efficacy and safety in different patient groups (pediatric, adult, high-risk).
  • Examination of co-administration strategies with other agents like propofol and midazolam.

Main Results:

  • Ketamine offers rapid onset and acceptable anesthesia via continuous infusion, suitable for total intravenous anesthesia.
  • It enables gentle anesthetic induction in children through various routes (oral, nasal, rectal, intramuscular).
  • Ketamine is valuable for high-risk adults, obstetric patients, those with hyperreactive airways, and for pain management in intensive care and chronic pain conditions.

Conclusions:

  • Ketamine is a versatile anesthetic and analgesic agent with broad clinical applications.
  • Its favorable properties make it suitable for diverse patient populations and surgical settings.
  • Adjuvant therapies can effectively manage ketamine's side effects, enhancing its clinical utility.

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