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Multidisciplinary treatment for gastric cancer patients by chemoimmunotherapy
H Yamaue1, H Tanimura, S Mizobata
1Second Department of Surgery, Wakayama Medical School, Japan. yamaue-h@wakayama-med.ac.jp
Background/Aims:
Gastric cancer is a virulent disease with a poor prognosis despite multidisciplinary treatment. The present study was designed to clarify the clinical effects of chemoimmunotherapy for patients with advanced gastric cancer.
Methodology:
The enrolled gastric cancer patients had distant metastases including liver (n = 2) and peritoneal dissemination (n = 21). The patients had received the chemotherapy according to the results of chemosensitivity test and adoptive immunotherapy by activated killer cells.
Results:
There were no severe toxicities, except fever and mild myelo-suppression. Four patients had complete response (17.4%) and 10 patients had partial response (43.5%). The performance status was improved in responders (p < 0.01, from 2.6 +/- 0.5 to 1.4 +/- 0.7); however, this was not changed in non-responders (from 2.2 +/- 0.9 to 2.0 +/- 1.2). The survival of responders was longer than that of non-responders (p < 0.05, 198 +/- 69 days vs. 104 +/- 68 days).
Conclusions:
It was clarified that responders by chemoimmunotherapy had a good quality of life and longer survival.