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Familial subarachnoid hemorrhage. Outcome study.
A Ronkainen1, M Niskanen, R Piironen
1Department of Neurosurgery, University Hospital of Kuopio, Kuopio, Finland. antti.ronkainen@kuh.fi
Stroke
|May 7, 1999
Summary
Familial subarachnoid hemorrhage (SAH) outcomes are similar to sporadic SAH. Familial SAH is not a significant risk factor for poor outcomes in this Finnish population.
Area of Science:
- Neurology
- Genetics
- Public Health
Background:
- Subarachnoid hemorrhage (SAH) can be familial or sporadic.
- Previous studies suggested familial SAH might lead to poorer outcomes.
Purpose of the Study:
- To compare outcomes and determinants between familial and sporadic aneurysmal subarachnoid hemorrhage (SAH).
- To investigate if familial SAH is an independent risk factor for poor prognosis.
Main Methods:
- A retrospective study of aneurysmal SAH patients treated between 1977-1995.
- Exclusion of patients with polycystic kidney disease.
- Assessment of outcomes using the Glasgow Outcome Scale (GOS) at 12 months.
Main Results:
- No significant differences in age, gender, or admission grade between familial (120 patients) and sporadic (1237 patients) SAH groups.
- Similar good outcomes (GOS 1-2) in both groups: 73% for familial SAH and 71% for sporadic SAH.
- No significant differences found in various clinical and radiological factors, and familial SAH was not an independent prognostic factor.
Conclusions:
- Admission status, postoperative course, and outcomes were similar in familial and sporadic SAH groups.
- Familial SAH does not appear to be a significant risk factor for poor outcomes in this Finnish population.
- Findings contrast with previous research, highlighting the need for further investigation.