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Related Experiment Video

Updated: Jan 26, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Lipoprotein (a) levels, apolipoprotein (a) phenotypes and thyroid autoimmunity.

E T Bairaktari¹, A D Tselepis, H J Millionis

¹Biochemistry Laboratory, University Hospital, Ioannina, Greece.

European Journal of Endocrinology

|May 7, 1999

Summary

Thyroid autoimmunity does not appear to influence lipoprotein (a) [Lp(a)] levels. This study found no significant differences in Lp(a) concentrations or apolipoprotein (a) [apo(a)] isoform frequencies between patients with and without thyroid autoimmunity.

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Published on: May 9, 2019

Area of Science:

Endocrinology and Metabolism
Cardiovascular Research
Immunology

Background:

Elevated serum lipoprotein (a) [Lp(a)] levels have been observed in euthyroid, normolipidemic males and postmenopausal females.
A known inverse correlation exists between Lp(a) concentration and apolipoprotein (a) [apo(a)] isoform size.
Previous reports suggest a potential association between thyroid autoimmunity and increased Lp(a) concentrations.

Purpose of the Study:

To investigate the association between thyroid autoimmunity and serum lipoprotein (a) [Lp(a)] levels.
To determine if apolipoprotein (a) [apo(a)] isoform frequencies differ between individuals with and without thyroid autoimmunity.
To verify if thyroid autoimmunity is independently linked to elevated Lp(a) concentrations, independent of apo(a) isoform size.

Main Methods:

Apolipoprotein (a) [apo(a)] phenotypes were determined in 22 patients with thyroid autoimmunity and 64 age- and sex-matched controls.
Serum Lp(a) levels and lipid parameters were measured in both groups.
Analysis included subgroups based on low vs. high molecular weight apo(a) isoforms.

Main Results:

No significant differences in lipid parameters, including Lp(a) levels, were found between patients with and without thyroid autoimmunity.
Apolipoprotein (a) [apo(a)] phenotype frequencies were similar in both the thyroid autoimmunity and control groups.
Median serum Lp(a) levels did not differ significantly between patients and controls, irrespective of apo(a) isoform size.

Conclusions:

The findings contradict previous reports suggesting an association between thyroid autoimmunity and elevated Lp(a) concentrations.
Thyroid autoimmunity does not appear to be an independent determinant of serum Lp(a) levels in this study population.
The study highlights the importance of considering apo(a) isoform frequencies when evaluating Lp(a) associations.