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[Radiotherapy in primary cerebral lymphoma]
L Legros1, K Benezery, J L Lagrange
1Département de radiothérapie, centre Antoine-Lacassagne, Nice, France.
Summary
Primary cerebral lymphoma treatment involves whole brain radiotherapy, with doses between 40-50 Gy. Combining radiotherapy with chemotherapy, particularly high-dose methotrexate, may improve survival for this rare brain cancer.
Area of Science:
- Neuro-oncology
- Radiation Oncology
Background:
- Primary cerebral lymphoma is a rare brain malignancy with a poor prognosis.
- Whole brain radiotherapy is the standard treatment, but optimal parameters remain undefined.
Purpose of the Study:
- To review current literature on primary cerebral lymphoma treatment.
- To discuss optimal radiotherapy fields, dosage, and the role of chemotherapy.
Main Methods:
- Literature review of primary cerebral lymphoma treatment strategies.
- Analysis of radiotherapy parameters (fields and dose) and chemotherapy combinations.
Main Results:
- Whole brain radiotherapy is recommended, with a potential boost to the primary site.
- A minimum dose of 40 Gy and a maximum of 50 Gy is suggested due to late sequelae risks.
- Chemotherapy, especially high-dose methotrexate, combined with radiotherapy shows a survival advantage.
Conclusions:
- Optimal radiotherapy fields and doses require further investigation.
- Chemotherapy combined with radiotherapy is a promising approach for primary cerebral lymphoma.
- Randomized trials are challenging due to disease rarity, necessitating further research into chemotherapy regimens.