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Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors
B Bachand1, J DiMaio, M A Siddiqui
1BioChem Therapeutic Inc., Laval, Québec, Canada.
Bioorganic & Medicinal Chemistry Letters
|May 7, 1999
Abstract:
A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.