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Adenosine receptor ligands with oxygenated N6-substituents
S A Hutchinson1, S P Baker, P J Scammells
1School of Biological & Chemical Sciences, Deakin University, Geelong, Vic, Australia.
Bioorganic & Medicinal Chemistry Letters
|May 7, 1999
Abstract:
A number of novel adenosine analogs bearing oxygenated substituents in the N6-position have been prepared and evaluated as A1 adenosine agonists. Improved conditions for the synthesis of N6-substituted adenosines and a new one pot procedure for the synthesis of 2-amino-7-oxabicyclo[2.2.1]hept-5-ene are also reported.