Related Experiment Videos
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase
P J Connolly1, S K Wetter, K N Beers
1The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA.
Bioorganic & Medicinal Chemistry Letters
|May 7, 1999
Abstract:
Two series of compounds (1 and 2) having structural features of the dual COX/5-LO inhibitor tepoxalin and the 5-LO inhibitor ABT-761 were prepared. Many of these hybrid compounds are potent COX and 5-LO inhibitors; two compounds (1a and 2t) inhibit eicosanoid biosynthesis in an ex vivo assay.