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N-(4-bromobenzoyl)-S,S-dimethyliminosulfurane, a potent dermal penetration enhancer
L Strekowski1, M Henary, N Kim
1Department of Chemistry, Georgia State University, Atlanta 30303, USA.
Bioorganic & Medicinal Chemistry Letters
|May 7, 1999
Abstract:
N-Aroyl-, N-Arylsulfonyl-, and N-Aryl-S,S-dimethyliminosulfuranes have been synthesized and evaluated as potential dermal penetration enhancers. The title compound and Azone exhibit similar activities for permeation of hydrocortisone through hairless mouse skin.