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Deficient platelet-activating factor and related enzymes in hemimegalencephaly
Y Hirashima1, S Endo, K Karasawa
1Department of Neurosurgery, Toyama Medical and Pharmaceutical University, Japan. yhira@ms.toyama-mpu.ac.jp
Abstract:
Platelet-activating factor (PAF) may influence neuronal migration, and gyral anomaly in hemimegalencephaly is believed to result from a neuronal disorder. A 7-month-old girl with hemimegalencephaly presented with intractable seizures, for which graded hemispherectomy was performed. In the resected specimen, we could not detect PAF, and related enzyme activities were low. These results suggest a role of PAF in neuronal migration.