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Immunoprotective effect of IM-133
S K Mitra1, M Gupta, T Suryanarayana
1R&D Centre, The Himalaya Drug Company, Makali, Bangalore, India.
International Journal of Immunopharmacology
|May 7, 1999
Summary
This study shows that the poly-herbal formulation IM-133 protects against E. coli-induced sepsis in mice. IM-133 enhances immune responses, offering potential for treating intracellular pathogen infections.
Area of Science:
- Immunology
- Pharmacology
- Microbiology
Background:
- Intra-abdominal sepsis, often caused by Escherichia coli (E. coli), is a life-threatening condition.
- Current treatments for sepsis have limitations, necessitating the exploration of novel therapeutic agents.
- Poly-herbal formulations are gaining attention for their potential immunomodulatory properties.
Purpose of the Study:
- To investigate the immunoprotective effects of IM-133, a poly-herbal formulation, against E. coli-induced intra-abdominal sepsis.
- To evaluate the impact of IM-133 on key immune parameters, including nitric oxide production and phagocytic activity.
- To determine the potential application of IM-133 in managing intracellular pathogen infections.
Main Methods:
- Balb/c mice were subjected to E. coli-induced intra-abdominal sepsis.
- Treatment groups received the poly-herbal formulation IM-133.
- Nitric oxide production and peritoneal macrophage phagocytic ability against Candida albicans were assessed in vivo.
Main Results:
- Treatment with IM-133 significantly reduced mortality associated with septic shock.
- In vivo administration of IM-133 enhanced nitric oxide production.
- IM-133 treatment improved the phagocytic capacity of peritoneal macrophages against Candida albicans.
Conclusions:
- IM-133 demonstrates significant immunoprotective effects against E. coli-induced intra-abdominal sepsis.
- The observed protective effects are attributed to the immunomodulatory activity of IM-133.
- IM-133 shows promise as an adjunct therapy for infections involving intracellular pathogens.