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Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development:

I Oishi1, S Takeuchi, R Hashimoto

  • 1Department of Biochemistry, Kobe University, School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650, Japan.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
|May 7, 1999
PubMed
Abstract

Insights

Murine Ror1 and Ror2 receptor tyrosine kinases (RTKs) show distinct expression patterns during nervous system development. Their differential regulation suggests unique roles in neural development.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Molecular Biology

Background:

  • The Ror-family of receptor tyrosine kinases (RTKs) includes Drosophila Dror/Dnrk and human Ror1/Ror2.
  • Mammalian Ror-family RTKs' expression and function remain largely uncharacterized.

Purpose of the Study:

  • To identify and characterize murine Ror-family RTKs (mRor1 and mRor2).
  • To investigate the developmental expression patterns of mRor1 and mRor2 in vitro and in vivo.

Main Methods:

  • Identification of murine Ror-family RTKs.
  • Analysis of gene induction during P19EC cell neuronal differentiation.
  • In vivo expression analysis during embryogenesis and postnatally.

Main Results:

  • Both mRor1 and mRor2 genes are induced during neuronal differentiation.
  • mRor1 expression increases continuously, while mRor2 expression is transiently induced during in vitro differentiation.
  • mRor1 is expressed in the developing nervous system and lens, sustained postnatally.
  • mRor2 is broadly expressed in the developing nervous system and declines after birth.

Conclusions:

  • Differential developmental expression of mRor1 and mRor2 in the nervous system.
  • These distinct patterns suggest specialized roles for mRor1 and mRor2 in nervous system development.

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