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Homologation of alpha-amino acids to beta-amino acids using Fmoc-amino acid pentafluorophenyl esters
1Department of Studies in Chemistry, Central College Campus, Bangalore University, India.
Abstract:
The homologation of alpha-amino acids to beta-amino acids by the two-step Arndt-Eister method is achieved by using Fmoc-alpha-amino acid pentafluorophenyl esters for the acylation of diazomethane, synthesizing the key intermediates Fmoc-aminoacyldiazomethanes as crystalline solids in good yields and purity.