[Humoral factors in the regulation of the natriuretic function of the kidneys]

Acute experiments were conducted on dogs. Intravenous injection of adrenalin (1--2 Mg/kg/min) caused an increase in the blood renin content and a reduction of the renal excretion of sodium, potassium and water. Noradrenaline (1--2 Mg/kg/min) produced the contrary changes in the renin secretion and diuresis, this being associated with a different activity of catecholamines in respect to tha alpha- and beta-adrenoreceptors. It is supposed that in acute hemodynamic shifts renin could play the role of intrarenal mediator of the natriuretic reaction.