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SAPHO syndrome: 20-year follow-up
A M Davies1, A J Marino, N Evans
1Department of Radiology, Royal Orthopaedic Hospital, Birmingham, UK.
Skeletal Radiology
|May 8, 1999
Summary
SAPHO syndrome, a rare condition, can present with unusual bone lesions. This case highlights a delayed diagnosis due to initial misinterpretation as osteosarcoma, emphasizing the importance of recognizing SAPHO syndrome
Area of Science:
- Rheumatology
- Radiology
- Orthopedic Oncology
Background:
- The Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) syndrome is a complex inflammatory disorder.
- Radiological manifestations of SAPHO syndrome have been increasingly recognized over the last decade.
Observation:
- This report details an atypical case of SAPHO syndrome with an initial femoral lesion misdiagnosed as parosteal osteosarcoma.
- The patient later developed a scapular lesion and typical sternoclavicular involvement, leading to a correct SAPHO diagnosis 19 years later.
Findings:
- SAPHO syndrome can present with diverse and initially misleading radiological findings.
- Delayed diagnosis is possible, particularly when lesions mimic other bone pathologies like osteosarcoma.
Implications:
- This case underscores the importance of considering SAPHO syndrome in the differential diagnosis of bone lesions, even with atypical presentations.
- Awareness of the varied radiological spectrum is crucial for timely and accurate diagnosis of SAPHO syndrome.