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[Sildenafil (Viagra). Tolerance, contraindications, drug interactions]
H Sperling1, M C Michel, H Rübben
1Urologische Klinik, Universitätsklinikum Essen.
Der Urologe. Ausg. A
|May 8, 1999
Summary
Sildenafil effectively treats erectile dysfunction, but its overall tolerability requires further assessment. Physicians must carefully consider patient factors like heart disease and age for safe prescription.
Area of Science:
- Pharmacology
- Urology
- Clinical Medicine
Background:
- Erectile dysfunction (ED) is a common condition affecting many men.
- Sildenafil has emerged as a treatment option for ED.
- Understanding the efficacy and safety profile of sildenafil is crucial for clinical practice.
Purpose of the Study:
- To evaluate the efficacy of sildenafil in treating erectile dysfunction.
- To assess the overall tolerability and safety of sildenafil based on available data.
- To identify specific patient populations and conditions requiring special attention during sildenafil prescription.
Main Methods:
- Review of placebo-controlled studies on sildenafil for erectile dysfunction.
- Analysis of reported tolerability data and adverse events.
- Identification of contraindications and factors influencing drug safety.
Main Results:
- Placebo-controlled studies confirm sildenafil's efficacy in treating erectile dysfunction.
- Definitive conclusions on sildenafil's overall tolerability are pending further data.
- Established contraindications include allergies, nitrate use, and retinitis pigmentosa.
- Special precautions are advised for patients with coronary heart disease, advanced age, liver impairment, and those on interacting medications.
Conclusions:
- Sildenafil is an effective treatment for erectile dysfunction.
- Comprehensive tolerability assessment requires additional research.
- Physician vigilance regarding patient-specific factors is essential for optimizing sildenafil safety and efficacy.