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Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda
Planta Medica
|May 8, 1999
Abstract:
Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Leishmania major in vitro.