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Transforming growth factor-beta1, a strong costimulator of rat T-cell activation promoting a shift towards a Th2-like

A Schiött1, B Widegren, H O Sjögren

  • 1The Wallenberg Laboratory, Department of Tumor Immunology, University of Lund, Sweden. asa.schiott@wblab.lu.se

Immunology Letters
|May 8, 1999
PubMed

TGF-beta is a known regulator of hematopoietic cells. In this study we suggest a major role of adherent spleen cells (adh-splc), to convert an inhibitory effect of TGF-beta1 on T-cell activation into a stimulatory effect. We show that interaction of TGF-beta1 with adh-splc induces a costimulatory effect on T-cell proliferation. This costimulatory signal requires the adh-splc to be in physical contact with the T-cells. Presence of adh-splc results in a shift towards a Th2-like response with a cytokine profile of increased IL-10 and decreased IFN-gamma. In the adh-splc population the increase of IL-10 is most pronounced at start of activation, whereas in the T-lymphocyte population, IL-10 increases at the end of culture. The suppression of the IFN-gamma production by TGF-beta1 is shown to be an important mechanism by which TGF-beta enhances proliferation of Th2 lymphocytes.

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