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Influences of microbiota on intestinal immune system development
1Department of Biology, the University of Pennsylvania, Philadelphia 19104-6018, USA. jcebra@sas.upenn.edu
The American Journal of Clinical Nutrition
|May 8, 1999
Abstract:
The normal colonization of the mammalian intestine with commensal microbes is hypothesized to drive the development of the humoral and cellular mucosal immune systems during neonatal life and to maintain the physiologically normal steady state of inflammation in the gut throughout life. Neonatal conventionally reared mice and germ-free, deliberately colonized adult mice (gnotobiotic mice) were used to examine the efficacy of certain intestinal microbes.