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Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
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Related Experiment Video

Updated: Jul 25, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

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Published on: February 26, 2013

Radiofrequency multielectrode catheter ablation in the atrium.

D Panescu1, S D Fleischman, J G Whayne

  • 1Boston Scientific, San Jose, CA 95134, USA.

Physics in Medicine and Biology
|May 8, 1999
PubMed
Summary

This study introduces a novel temperature-controlled radiofrequency system for creating contiguous lesions. The system safely and effectively ablates tissue, demonstrating potential for therapeutic applications in cardiac procedures.

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Area of Science:

  • Medical Devices
  • Biomedical Engineering
  • Electrophysiology

Background:

  • Radiofrequency (RF) ablation is a common therapeutic procedure.
  • Achieving contiguous and transmural lesions is crucial for effective ablation.
  • Existing systems may have limitations in controlling lesion size and contiguity.

Purpose of the Study:

  • To develop and evaluate a novel temperature-controlled RF system for simultaneous ablation using multiple electrodes.
  • To assess the system's ability to create long, contiguous, and potentially therapeutic lesions.
  • To analyze the performance and safety of the system in vitro and in vivo.

Main Methods:

  • A temperature-controlled RF generator with a microcontroller and electronic switches was developed.
  • The system delivered energy to up to six 12.5 mm coil electrodes simultaneously.
  • Temperature feedback was obtained from sensors at each electrode, regulating power to maintain a set temperature within a 5°C interval.
  • Finite element models and current density measurements were used for physical analysis.
  • Performance was evaluated in vitro and in vivo (canine right atria).

Main Results:

  • In vitro studies showed that 85-100% of lesions were contiguous at set temperatures of 70-90°C.
  • Lesion length increased linearly with the number of electrodes used.
  • In vivo, contiguous lesions were created in canine right atria with 75% being potentially therapeutic (transmural and covering the target region).
  • No sudden impedance rises occurred during in vivo procedures.
  • Average procedure and fluoroscopy times were 83.4 and 5.9 minutes, respectively.

Conclusions:

  • The developed temperature-controlled RF system can safely create long and contiguous lesions.
  • The system demonstrates promising results for therapeutic ablation, particularly in cardiac applications.
  • Simultaneous multi-electrode ablation with precise temperature control enhances lesion efficacy and safety.