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Sympathetic adaptations to one-legged training.

C A Ray1

  • 1Cardiovascular Center and Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA. caray@psu.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 8, 1999
PubMed
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Leg exercise training reduces sympathetic nerve activity during exercise. This study shows that 6 weeks of training prolongs the decrease in muscle sympathetic nerve activity (MSNA) during leg exercise.

Area of Science:

  • Exercise Physiology
  • Autonomic Nervous System Regulation
  • Cardiovascular Adaptations to Training

Background:

  • Sympathetic nerve activity (SNA) plays a crucial role in cardiovascular regulation during exercise.
  • Previous research indicated that forearm exercise training can attenuate SNA responses.
  • The impact of leg exercise training on SNA during dynamic leg exercise remained less understood.

Purpose of the Study:

  • To investigate the effects of a 6-week leg exercise training program on sympathetic nerve responses.
  • To assess changes in muscle sympathetic nerve activity (MSNA) at rest and during dynamic leg exercise.
  • To compare MSNA responses before and after the training intervention.

Main Methods:

  • Six healthy men underwent a 6-week training program involving high-intensity interval and prolonged continuous one-legged cycling.
Keywords:
NASA Discipline NeuroscienceNon-NASA Center

Related Experiment Videos

  • Measurements included heart rate, mean arterial pressure (MAP), and peroneal nerve MSNA.
  • Participants performed 3 minutes of upright dynamic one-legged knee extensions at 40 W before and after the training period.

    • Main Results:

    • Peak oxygen uptake in the trained leg increased by 19% post-training.
    • Resting heart rate decreased, while resting MAP and MSNA showed no significant changes.
    • During exercise, heart rate and MAP were lower post-training.
    • MSNA decreased similarly from rest during the initial exercise minutes, but was significantly lower during the third minute of exercise after training.

    Conclusions:

    • Six weeks of leg exercise training prolongs the decrease in MSNA during upright leg exercise.
    • The findings suggest that leg exercise training, similar to forearm training, leads to an attenuation of sympathetic nerve responses to exercise.
    • These results highlight the adaptability of the autonomic nervous system to specific exercise training modalities.