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Diffuse necrobiosis lipoidica diabeticorum associated with non-insulin dependent diabetes mellitus
S Imakado1, H Satomi, M Iskikawa
1Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba, Ibaraki 305-8575, Japan.
Clinical and Experimental Dermatology
|May 8, 1999
Abstract:
We report a case of diffuse necrobiosis lipoidica (NL) which first appeared on the legs and scrotum, before gradually spreading across the back and arms; the patient also suffered from diabetes mellitus, and the NL lesion began to disappear as the diabetes mellitus was controlled. The possible contribution of various glycation and glycoxidation products of collagen to the pathogenesis of NL is discussed.