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Dry coating: an innovative enteric coating method using a cellulose derivative.

S Obara1, N Maruyama, Y Nishiyama

  • 1Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd., Niigata, Japan.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|May 11, 1999
PubMed
Summary

A new dry enteric coating method uses polymer powder and plasticizers without solvents. This innovative technique significantly reduces processing time for enteric-coated beads and tablets.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Conventional enteric coating processes often rely on organic solvents or water, posing environmental and efficiency challenges.
  • Developing solvent-free coating methods is crucial for sustainable and streamlined pharmaceutical manufacturing.

Purpose of the Study:

  • To develop and evaluate a novel, solvent-free enteric coating method for pharmaceutical dosage forms.
  • To assess the efficacy of this dry coating technique using hydroxypropyl methylcellulose acetate succinate.

Main Methods:

  • A direct powder-feeding and plasticizer-spraying technique was employed using centrifugal granulators, fluidized beds, or tablet coaters.
  • A post-coating curing step involving minimal water or HPMC solution and heating was utilized for film formation.
  • Coated beads and tablets were compared against conventionally aqueous-coated counterparts for performance.

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Main Results:

  • The novel dry coating method achieved effective gastric resistance and intestinal disintegration.
  • A higher coating amount was needed compared to conventional aqueous coating for equivalent gastric resistance.
  • Processing time was substantially reduced, demonstrating significant efficiency gains.

Conclusions:

  • This solvent-free dry coating method is a viable and efficient alternative for preparing enteric-coated beads and tablets.
  • The technique is applicable using standard laboratory-scale equipment, facilitating wider adoption.
  • Further optimization may be explored to match coating efficiency with conventional methods.