Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Invasive meningococcal infection in Western Australia.

C A Olesch1, G J Knight

  • 1Department of Paediatrics, Princess Margaret Hospital for Children, Subiaco, Western Australia.

Journal of Paediatrics and Child Health
|May 11, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The reference range and within-person variability of thyroid stimulating hormone during the first and second trimesters of pregnancy.

Journal of medical screening·2004
Same author

Assigning risk for Smith-Lemli-Opitz syndrome as part of 2nd trimester screening for Down's syndrome.

Journal of medical screening·2002
Same author

Clinical validation of a new dimeric inhibin-A assay suitable for second trimester Down's syndrome screening.

Journal of medical screening·2001
Same author

Anaesthesia and pain management in cerebral palsy.

Anaesthesia·1999
Same author

Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child.

The New England journal of medicine·1999
Same author

Antepartum fetal and maternal carboxyhemoglobin and cotinine levels among cigarette smokers.

Acta paediatrica (Oslo, Norway : 1992)·1999

Meningococcal infection in children presents with fever and rash, with purpura indicating higher mortality risk. Aboriginal children and infants under 3 months showed increased incidence and specific risk factors.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Clinical Microbiology

Background:

  • Meningococcal infection is a significant cause of morbidity and mortality in children.
  • Understanding the clinical presentation, demographic distribution, and risk factors is crucial for timely diagnosis and management.
  • Previous studies have highlighted variations in disease patterns across different populations and age groups.

Purpose of the Study:

  • To review the signs and symptoms of meningococcal infection in children.
  • To analyze the age, sex, and race distribution of meningococcal infections.
  • To assess the association between presenting features and patient outcomes, including morbidity and mortality.

Main Methods:

  • A retrospective review of case notes was conducted over a 5-year period.

Related Experiment Videos

  • Data from 105 pediatric patients (19 days to 13 years) were analyzed.
  • Key variables included vital signs, rash characteristics, demographics, and patient outcomes.

    • Main Results:

    • Fever (89.5%), tachypnea (73.3%), and rash (59%) were the most frequent presenting symptoms.
    • Purpura and reduced systolic blood pressure were significantly associated with increased mortality.
    • The incidence in Aboriginal children was approximately six times higher than in non-Aboriginal children; 17.1% of cases were initially misdiagnosed, predominantly in children under 2 years.

    Conclusions:

    • Meningococcal infection in children is characterized by fever and rash, with specific signs like purpura predicting poor outcomes.
    • Significant demographic disparities exist, with higher incidence in Aboriginal populations and a male preponderance in neonates.
    • Timely diagnosis is critical, as initial misdiagnosis, particularly in young children, can lead to adverse outcomes.