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Related Experiment Video

Updated: Jul 8, 2026

Isolation of Brain-infiltrating Leukocytes
06:44

Isolation of Brain-infiltrating Leukocytes

Published on: June 13, 2011

Theiler's virus-induced central nervous system disease in mice.

H L Lipton, M C Canto

    UCLA Forum in Medical Sciences
    |January 1, 1976
    PubMed
    Summary
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    Theiler's viruses cause a biphasic neurological disease in mice, starting with motor neuron damage and paralysis, followed by persistent infection and demyelination leading to late-onset neurological dysfunction.

    Area of Science:

    • Neurovirology
    • Immunology
    • Pathology

    Background:

    • Theiler's viruses (TV) are common enteric pathogens in mice.
    • TV causes a biphasic neurological disease after IC inoculation, affecting the central nervous system (CNS).

    Purpose of the Study:

    • To characterize the early and late phases of Theiler's virus infection in mice.
    • To investigate the role of host immunity in disease progression and demyelination.

    Main Methods:

    • Intracranial (IC) inoculation of mice with Theiler's viruses.
    • Observation of clinical signs, pathological lesions (neuron degeneration, demyelination), and immune responses.
    • Assessment of host susceptibility using SJL/J inbred strain.

    Main Results:

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    Last Updated: Jul 8, 2026

    Isolation of Brain-infiltrating Leukocytes
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    Isolation of Brain-infiltrating Leukocytes

    Published on: June 13, 2011

    Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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    Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

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    A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
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    • Early phase: virus replication in CNS gray matter, motor neuron degeneration, and flaccid paralysis.
    • Late phase: persistent infection, mononuclear infiltration, primary demyelination, and a distinct neurological disorder.
    • Delayed humoral and cell-mediated immune responses to TV antigen, atypical for acute infections.

    Conclusions:

    • Theiler's virus infection leads to a chronic, biphasic neurological disease with potential immune-mediated demyelination.
    • Further research is needed to identify cells supporting chronic virus replication and mechanisms of persistent infection.